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Works where it matters most: the digestive tract.1

Take 3 capsules with 16 ounces of water 20 minutes before lunch and dinner.1

A nonsystemic aid made with naturally derived building blocks designed to help patients feel fuller.1

Super absorbent hydrogel particles are released, absorb water, and expand to 100x their weight with significant elasticity and firmness.1,2

Particles remain fully hydrated through the small intestine to promote feeling of satiety.1

Particles degrade in the large intestine, release water back into body, and are eliminated.1,2

Plenity Mechanism of Action:

See Plenity® in action

Intended Use

Plenity® is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 25–40 kg/m², when used in conjunction with diet and exercise.


Important Safety Information

  • Plenity is contraindicated in patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide
  • Plenity may alter the absorption of medications. Read Sections 6 and 8.3 of the Instructions for Use carefully
  • Avoid use in patients with: esophageal anatomic anomalies, including webs, diverticuli, and rings; suspected strictures (such as patients with Crohn’s disease); and complications from prior gastrointestinal (GI) surgery that could affect GI transit and motility
  • Use with caution in patients with active gastrointestinal conditions such as gastro-esophageal reflux disease (GERD), ulcers, or heartburn
  • The overall incidence of AEs in the Plenity group was no different than the placebo group
  • The most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence

Rx Only. For the safe and proper use of Plenity, refer to the Healthcare Professionals Instructions for Use.

  1. Plenity [Instructions for Use]. Boston, MA: Gelesis, Inc.; 2021.
  2. Greenway FL, Aronne LJ, RabenA, et al. A randomized, double-blind, placebo-controlled study of Gelesis100: a novel nonsystemicoral hydrogel for weight loss. Obesity. 2019;27(2):205–216.